ABSTRACT
Aim To explore the effect of soybean meal on bone metabolism in ovariectomized osteoporosis rat-sandits mechanism. Methods Three-month-old SPF-class SD female rats were randomly divided into sham operation group, model group, estradiol group and soybean meal administration group, with 8 rats in each group. One week after the operation, the corresponding drug was administered by gavage for 8 weeks. After 8 weeks, the bone mineral density (BMD) and uterus index of each group were measured. Biomarkers for ovariectomized osteoporosis rats were identified by urinary metabolomics. Results (1) Soybean meal could significandy increase BMD and uterine index of femur in ovariectomized rats in model group,and significantly reduce the weight of ovariectomized ratsin model group. (2) 23 biomarkers and 9 metabolic pathways closely related to postmenopausal osteoporosiswere i-dentified. Soybean meal could significantly exert a callback effect on 12 biomarkers by regulating various metabolic pathways, such as steroid hormone biosynthesis metabolism, inositol phosphate metabolism, primary bile acid biosynthesis metabolism and purine metabolism. Conclusions Soybean meal can effectively interfere with the occurrence and development of postmenopausal osteoporosis. This study provides scientific data for the prevention and treatment of postmenopausal osteoporosis drugs.